Comparison
of the fragility index of different eudragit polymers determined by activation
enthalpies |
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| Authors: | Gabriella Csóka A Gelencsér Dorottya Kiss Eszter Pásztor I Klebovich Romána Zelkó |
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| Institution: | (1) Department of Pharmaceutics, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. Str. 7.;(2) University Pharmacy Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. Str. 7–9. |
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| Abstract: | The present study aimed to apply fragility
index (m) of polymers in the determination
of the optimal amount of plasticizer in polymer films. The fragility index
of different Eudragit polymers (RS, RL, EPO) was assessed by differential
scanning calorimerty (DSC), applying the Arrhenius connection (logq–1/T
g).
The fragility of Eudragit EPO films proved to be the highest, while in the
case of RS and RL, the increase of the alkyl-chain length caused the increase
of fragility. Studying the effect of plasticizer (triethyl citrate, TEC) on
the m value of Eudragit RL and RS films,
a near linear reduction of the fragility index could be observed between 5–30%
TEC concentration, but above 30%, this value leveled out to constant. |
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| Keywords: | activation enthalpy EPO Eudragit fragility index RL RS triethyl citrate |
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