Synthesis of chiral cyclic oligothiazolines: a novel structural motif for a macrocyclic molecule |
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| Authors: | Han Fu She Osajima Hiroyuki Cheung Mui Tokuyama Hidetoshi Fukuyama Tohru |
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| Institution: | PRESTO, the Japan Science and Technology Agency (JST), 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | The synthesis of chiral cyclic oligo(4-beta-methyl)thiazolines is described; linear oligothiazolines were efficiently prepared by the iterative formation of a thiazoline ring and a two-directional block condensation, and construction of 24- to 36-membered cyclic oligothiazoline systems could be achieved by the head-to-tail cyclooligomerization of doubly deprotected linear fragments and subsequent thiazoline formation. |
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