生物催化不对称合成beta-羟基酸衍生物

手性β-羟基酸及其衍生物是应用化工和有机合成的关键中间体, 生物催化的不对称合成方法以其绿色环保, 简洁高效及高立体选择性已然成为一个新兴的研究热点。本文较系统的总结了生物催化的β-羟基酸及其衍生物不对称合成研究工作，重点介绍了脂肪酶，腈代谢酶及还原酶在合成手性β-羟基酸衍生物中的应用。最后，对今后生物催化不对称合成β-羟基酸的发展方向做一展望。

Biocatalytic Asymmetric Synthesis of beta-Hydroxy Acid derivatives

Chiral β-hydroxy acids are key intermidiates in chemical industry and organic synthesis. Biocatalytic asymmetric synthesis renders an enviromental benign, simple, efficient and high steroseletive method for production of chiral β-hydroxy acid derivatives. This mini-review systematically summarizes the progress of biocatalytic asymmetric synthesis of β-hydroxy acid and its derivatives with emphasis on biocatalyst as lipase, nitrile metabolism enzymes and reductase. The developing trends of biocatalytic asymmetric synthesis of β-hydroxy acids is also discussed.