| Taxuchin B,a New Chlorine-Containing Taxoid |
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| 摘 要： | ProjectSuppotedbyagrantfromTheNationalNaturalScienceFoundaionofChina.ChemicalstUdiesonTaxusspp.plantShavebeenextensivelycarriedoutsincetheisolationofanticancerdrugpacIitaxel(rtaxol@)fromstembarkofpacificyewTaxusbrevghld').Morethan2ootaxoidshavebeenisolatedfromGenusTaxusandAustrOtaxUSplantS<=).InordertoovercometaxoIsupplycrisis,manyusefulmethodswerederived.AInongthemsemisynthesisofpaclitaxelanditSanalogsfromitSprecursorssuchaslo-deacetyIbaccatinIIIwhichisabundantintherenewableneedles…
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