Culcitiolides A-D, four new eremophilane-type sesquiterpene derivatives from Senecio culcitioides |
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| Authors: | Nozaki Hiroshi Hayashi Ken-ichiro Kawai Mikiko Mitsui Taichi Kido Masahiro Tani Hiroyuki Takaoka Daisuke Uno Hidemitsu Ohira Susumu Kuboki Atsuto Matsuura Nobuyasu |
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| Institution: | Department of Biological Chemistry, Faculty of Science, Okayama University of Science, Okayama 700-0005, Japan. nozaki@dbc.ous.ac.jp |
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| Abstract: | Four new eremophilane-type sesquiterpenes, culcitiolides A-D, were isolated from the stem of Senecio culcitioides Sch. Bip (Asteraceae). Their structures were established by detailed 2D NMR spectroscopic and single-crystal X-ray experiments. These compounds were assessed for inhibitory activity against nuclear factor kappaB (NF-kappaB). Culcitiolides C and D at 20 microM showed 97 and 100% inhibition of NF-kappaB activity, respectively. |
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