New metabolites from the marine-derived fungus Aspergillus fumigatus |
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Authors: | Afiyatullov Shamil Sh Zhuravleva Olesya I Antonov Alexandr S Kalinovsky Anatoly I Pivkin Michail V Menchinskaya Ekaterina S Aminin Dmitry L |
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Affiliation: | Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok 690022, Russian Federation. afiyat@piboc.dvo.ru |
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Abstract: | A new alkaloid, fumiquinazoline K (1), and a new nordammarane triterpenoid (2), together with three known diketopiperazines (3-5) and tryptoquivaline F (6) have been isolated from a marine strain of Aspergillus fumigatus KMM 4 631 associated with the soft coral Sinularia sp. Their structures were determined by HR-MS and 1D and 2D NMR. Compounds 3-5 exhibit weak cytotoxicity against cytoplasm non-specific esterase in Ehrlich carcinoma cells. Compound 3 also induces early apoptosis of the same cells in a non-toxic range of concentrations. |
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