| 金属氯化物对硼氢化钠还原α-氯代苯乙酮的影响 |
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| 引用本文： | 王明慧,吴坚平,杨立荣,陈新志. 金属氯化物对硼氢化钠还原α-氯代苯乙酮的影响[J]. 有机化学, 2005, 25(12): 1548-1551 |
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| 作者姓名： | 王明慧 吴坚平 杨立荣 陈新志 |
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| 作者单位： | 浙江大学化学与生物工程学系,杭州,310027 |
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| 摘 要： | 用NaBH4还原α-氯代苯乙酮制备相应的β-氯代-α-苯乙醇时, 在较高的反应温度下产生许多副产物, 钙、镧、镁、锰、锌等金属氯化物的存在能有效抑制副反应的发生, 高产率地得到产物.
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| 关 键 词： | β-氯代-α-苯乙醇 α-氯代苯乙酮 硼氢化钠 还原 金属氯化物 |
| 收稿时间： | 2004-09-05 |
| 修稿时间： | 2005-06-07 |
Effect of Metal Chlorides on the Reduction of α-Chloroacetophenones with Sodium Borohydride |
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| WANG,Ming-Hui,WU,Jian-Ping,YANG,Li-Rong,CHEN,Xin-Zhi. Effect of Metal Chlorides on the Reduction of α-Chloroacetophenones with Sodium Borohydride[J]. Chinese Journal of Organic Chemistry, 2005, 25(12): 1548-1551 |
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| Authors: | WANG Ming-Hui WU Jian-Ping YANG Li-Rong CHEN Xin-Zhi |
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| Affiliation: | Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 310027 |
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| Abstract: | During the synthesis of β-chloro-α-phenylethanols by reduction of α-chloroacetophenones with sodium borohydride, many byproducts were produced unavoidably at relatively high temperature. Metal chlorides such as calcium, lanthanum, magnesium, manganese and zinc chloride could efficiently restrain side reactions, and so the product was obtained in high yield. |
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| Keywords: | β-chloro-α-phenylethanol α-chloroacetophenone sodium borohydride reduction metal chloride |
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