Rapid Profiling of Alkaloids in Several Medicinal Herbs by Matrix-assisted Laser Desorption/Ionization Mass Spectrometry |
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| Authors: | LU Lin YUE Hao SONG Feng-rui TSAO Rong LIU Zhi-qiang LIU Shu-ying |
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| Affiliation: | [1]Changchun Center of Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China [2]Guelph Food Research Centre, Agriculture and Agri-Food Canada, 93 Stone Road West, Guelph, Ontario, N1G5C9, Canada [3]Graduate School, Chinese Academy of Sciences, Beijing 100049, P. R. China |
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| Abstract: | A simple method was developed for rapid and direct profiling of alkaloids in medical herbs via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS). The dry herbs were first ground to powder and passed through a stainless steel sieve, mixed with the matrix solution to form a homogeneous suspension, which was then directly applied to MALDI analysis. Several matrices were investigated and 2,5-dihydroxybenzoic acid(DHB) was chosen as the optimized one, and the particle wit... |
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| Keywords: | Matrix-assisted laser desorption/ionization Alkaloid Medical herb |
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