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| 非天然氨基酸引入法制备含有新型赖氨酸翻译后修饰蛋白质 | |
| 引用本文： | 王志鹏,李曼,程农壹,王田.非天然氨基酸引入法制备含有新型赖氨酸翻译后修饰蛋白质[J].化学教育,2018,39(18):9-13. |
| 作者姓名： | 王志鹏 李曼 程农壹 王田 |
| 作者单位： | 1. Department of Chemistry, Texas A&M University, College Station, TX, USA 77840; 2. 清华大学化学系 北京 100084; 3. Department of Plant Pathology and Microbiology, Texas A&M University, College Station, TX, USA 77840; 4. University of Wisconsin-Madison, Madison, WI, USA 53706; 5. Division of Biological Science, University of California San Diego, La Jolla, USA 92093 |
| 摘 要： | 近年来多种天然蛋白质中赖氨酸翻译后修饰被逐渐发现。这些翻译后修饰在蛋白质组中广泛存在，对染色体结构和基因转录表达功能具有重要的调控作用。然而，获得足量的具有特定翻译后修饰的蛋白质并非易事，发展制备方法对于后续表观遗传学研究极为重要。讨论了利用非天然氨基酸引入的手段制备含有这些新型赖氨酸翻译后修饰的蛋白。 |
| 关 键 词： | 赖氨酸 翻译后修饰 非天然氨基酸 蛋白质组 |
Brief Introduction of Non-Canonical Amino Acid Incorporation Technique for Introduction of Lysine Post-Translational Modifications into Proteins |
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| WANG Zhipeng,LI Man,CHENG Nong-Yi,WANG Tian.Brief Introduction of Non-Canonical Amino Acid Incorporation Technique for Introduction of Lysine Post-Translational Modifications into Proteins[J].Journal of Chemical Education,2018,39(18):9-13. | |
| Authors: | WANG Zhipeng LI Man CHENG Nong-Yi WANG Tian |
| Institution: | 1. Department of Chemistry, Texas A & M University, College Station, TX, USA 77840; 2. Department of Chemistry, Tsinghua University, Beijing 100084, China; 3. Department of Plant Pathology and Microbiology, Texas A & M University, College Station, TX, USA, 77840; 4. University of Wisconsin-Madison, Madison, WI, USA 53706; 5. Division of Biological Science, University of California San Diego, La Jolla, USA 92093 |
| Abstract: | |
| Keywords: | lysine post-translational modifications non-canonical amino acid proteome |
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