| 离子液体催化苯乙烯类化合物的氢烯基化和烷基化反应 |
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| 引用本文： | 刘慕文,杨化萌,张金龙,夏春谷,蒋高喜.离子液体催化苯乙烯类化合物的氢烯基化和烷基化反应[J].分子催化,2018,32(3):211-217. |
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| 作者姓名： | 刘慕文 杨化萌 张金龙 夏春谷 蒋高喜 |
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| 作者单位： | 中科院兰州化学物理研究所羰基合成与选择氧化国家重点实验室;中国科学院大学 |
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| 基金项目： | 中科院百人计划项目资助；国家自然科学基金（21602231）；江苏省自然科学基金（BK20151235，BK20160396） |
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| 摘 要： | Brnsted酸性离子液体作为反应介质和催化剂,实现了苯乙烯类化合物的氢烯基化反应和富电子芳烃参与的氢烷基化反应,取得了优秀的产率和选择性,其产率最高可达到97%,底物适应性比较好,易于放大到克量级,为反式1,3-二芳基1-丁烯化合物和1,1-二芳基乙烷类化合物的制备提供了绿色合成新途径,值得一提的是本方法能以85%的产率高效合成抗蛋白凝聚药物3i,表现出了很好的实用价值.
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| 关 键 词： | brønsted酸性离子液体 芳烃烷基化 烯烃烷基化 friedel-crafts烷基化 |
| 收稿时间： | 2018/3/10 0:00:00 |
| 修稿时间： | 2018/4/8 0:00:00 |
Hydroarylation and Hydroalkenylation of Vinylarenes by Brønsted Acidic Ionic Liquid |
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| LIU Mu-wen,YANG Hua-meng,ZHANG Jin-long,XIA Chun-gu and JIANG Gao-xi.Hydroarylation and Hydroalkenylation of Vinylarenes by Brønsted Acidic Ionic Liquid[J].Journal of Molecular Catalysis (China),2018,32(3):211-217. |
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| Authors: | LIU Mu-wen YANG Hua-meng ZHANG Jin-long XIA Chun-gu and JIANG Gao-xi |
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| Institution: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China;University of Chinese Academy of Science, Beijing 100000, China,State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China,State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China,State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China |
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| Abstract: | Both hydroarylations and hydroalkenylations of vinylarenes by the use of Brønsted acidic ionic liquids as reaction media and catalyst were reported. The green process provided a readily scalable, metal-free, and practical access to trans-1,3-diaryl-1-butenes and 1,1-diarylalkane scaffolds in good to excellent yields. |
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| Keywords: | brønsted acidic ionic liquids friedel-crafts-type alkylation hydroarylation hydroalkenylation |
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