Future light sources based upon photo-injected energy recovery linacs |
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Authors: | I Ben-zvi S Krinsky |
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Institution: | National Synchrotron Light Source, Brookhaven National Laboratory , Upton, NY, 11973, USA |
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Abstract: | X-ray scattering techniques have long ranked among the most important methods for studying amorphous materials and other highly disordered targets. Well-established X-ray scattering methods often consist of recording time-averaged scattered intensity maps which, under the Born approximation, straightforwardly reveal information about ensemble-averaged, two-point, electron density correlations within the target. In the case of isotropic targets that consist of disordered ensembles of randomly oriented particles, scattering data are typically reduced to a histogram of electron pair distances (the “pair distribution function,” or PDF). While the information contained in the one-dimensional PDF is limited, a rich set of structural properties can often be determined straightforwardly (e.g., radius of gyration, surface area, short-range correlation length scales, fractal dimension). One of the well-known pinnacles of the methodology is the application of small-angle X-ray scattering (SAXS) to solutions of identical biological macromolecules 1 Elser, V. 2011. New J. Phys., 13: 123014Crossref] , Google Scholar]–3 Putnam, C. D., Hammel, M., Hura, G. L. and Tainer, J. A. 2007. Quarterly Reviews of Biophysics, 40: 191–285. Crossref], PubMed], Web of Science ®] , Google Scholar]], which is now routinely used to rapidly determine ab initio low-resolution (>1 nm) protein structures 4 Hura, G. L. 2009. Nature Methods, 6: 606–614. Crossref], PubMed] , Google Scholar]]. |
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