| Synthesis of derivatives of imidazo[4,5-b]pyridine： Novel sulfur contained side chains for macrolide antibiotics |
| |
| 作者姓名： | Lu Liu Peng Xu Liang Zhou Ping Sheng Lei |
| |
| 作者单位： | Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100050, China |
| |
| 基金项目： | Finacial support of this research by the National Natural Science Foundation of China （No. 30572275） and Natural Science Foundation of Beijing （No. 7062047） are gratefully acknowledged by the authors. |
| |
| 摘 要： | Two series of novel derivatives of imidazo4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
|
| 关 键 词： | 咪唑 嘧啶 大环内酯 合成 杂芳化作用 |
| 收稿时间： | 2007-09-20 |
Synthesis of derivatives of imidazo[4,5-b]pyridine： Novel sulfur contained side chains for macrolide antibiotics |
| |
| Lu Liu Peng Xu Liang Zhou Ping Sheng Lei.Synthesis of derivatives of imidazo[4,5-b]pyridine： Novel sulfur contained side chains for macrolide antibiotics[J].Chinese Chemical Letters,2008,19(1):1-4. |
| |
| Authors: | Lu Liu Peng Xu Liang Zhou Ping Sheng Lei |
| |
| Institution: | Key Laboratory of Bioactivity Substance and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100050, China |
| |
| Abstract: | Two series of novel derivatives of imidazo4,5-b]pyridine were synthesized. These compounds could be used as side chains of semisynthesised ketolide antibiotics. The side chains have free amine group which can attached to ketolide core. Macrolides with this kind of side chains will show obvious activities against erythromycin-resistant strains. The structure of the side chains was confirmed by ^1H, ^13C NMR, MS, HMBC spectra. 2007 Ping Sheng Lei. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| |
| Keywords: | Macrolide Heterarylalkyl sulfur contained side chain Imidazo[4 5-b]pyridine Synthesis HMBC |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
