Four novel withanolide-type steroids from the leaves of Solanum cilistum. |
| |
| Authors: | X H Zhu J Ando M Takagi T Ikeda A Yoshimitsu T Nohara |
| |
| Institution: | Faculty of Pharmaceutical Sciences, Kumamoto University, Japan. |
| |
| Abstract: | Four novel withanolide-type steroids named cilistols p, pm, p1 and u (1-4, respectively), were isolated from the leaves of Solanum cilistum. The respective structures were characterized by spectroscopic means as follows: cilistol p (1) was (22R,24R,25R,26S)-1-oxo-22,26-epoxy-3alpha,5alpha-cycloergostane-6beta,17alpha, 24,25,26-pentaol 26-O-beta-D-glucopyranoside, cilistol pm (2) corresponded to the 6-O-methyl ether derivative of 1; cilistol p1 (3) was represented as the 24-O-methyl ether of 1, and cilistol u (4) was shown to be the epoxide between C-24 and -25, presumably bearing cilistols p, pm and p1 by ring-opening. |
| |
| Keywords: | |
|
|
