| Studies on Enantioselective Effect of Chiral Titanate Reagents on the Synthesis of Substituted Benzhydrols |
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| 作者姓名： | WANG Ji-tao FAN Xiu-ju FENG Xiao and LI Yue-ming |
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| 作者单位： | Department of Chemistry，Nankai University，Tianjin，300071 |
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| 基金项目： | Supported by the Grant of National Natural Science Foundation of China，the Organometallic Chemistry Laboratory of the Shanghai Institute of Organic Chemistry, Chinese Academy of Science |
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| 摘 要： | Chiral titanate reagents were prepared for inducing asymmetric syntheses of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature and exchange of reactants by crossing experiments were investigated. Favorable attack of the nucleophile upon the aromatic aldehydes' prochiral face was proposed, the absolute configurations of the synthesized benzhydrols were suggested, and a preliminary reaction mechanism was described.
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Studies on Enantioselective Effect of Chiral Titanate Reagents on the Synthesis of Substituted Benzhydrols |
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| WANG Ji-tao FAN Xiu-ju,FENG Xiao and LI Yue-ming.Studies on Enantioselective Effect of Chiral Titanate Reagents on the Synthesis of Substituted Benzhydrols[J].Chemical Research in Chinese University,1993(1). |
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| Authors: | WANG Ji-tao FAN Xiu-ju FENG Xiao and LI Yue-ming |
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| Abstract: | Chiral titanate reagents were prepared for inducing asymmetric syntheses of substituted benzhydrols from Grignard reagents and aldehydes. The solvents, reaction temperature and exchange of reactants by crossing experiments were investigated. Favorable attack of the nucleophile upon the aromatic aldehydes' prochiral face was proposed, the absolute configurations of the synthesized benzhydrols were suggested, and a preliminary reaction mechanism was described. |
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| Keywords: | Asymmetric synthesis Benzhydrols Chiral titanates |
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