| 1,3,4-噻二唑基芳酰基脲的合成和生物活性 |
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| 引用本文： | 韩锋,万嵘,王瑶,王朋,王锦堂. 1,3,4-噻二唑基芳酰基脲的合成和生物活性[J]. 有机化学, 2010, 30(1): 132-136 |
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| 作者姓名： | 韩锋 万嵘 王瑶 王朋 王锦堂 |
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| 作者单位： | 南京工业大学理学院,南京,210009 |
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| 基金项目： | 2007年度江苏省高技术研究计划(农业) (NO.BG2007329)和南京工业大学博士创新基金(NO.BSCX200717) |
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| 摘 要： | 以2-氨基-5-取代苯基-1,3,4噻二唑和2,6-二氟苯甲酰异氰酸酯为起始原料，合成了10个未见文献报道的含1,3,4-噻二唑环的芳酰基脲类衍生物。通过1H NMR，IR，ESI-MS和元素分析确定化合物的结构。初步生物活性测试表明，此类化合物具有一定的杀虫活性，其中化合物3d (3,5-(CH3)2)和3g (4-C4H9)对蚕豆蚜的杀虫死亡率达到90%以上.
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| 关 键 词： | 1,3,4-噻二唑 芳酰基脲 合成 生物活性 |
| 收稿时间： | 2009-03-25 |
| 修稿时间： | 2009-07-19 |
Synthesis and Biological Activity of 1,3,4-Thiadiazole Aroylurea Derivatives |
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| Han Feng,Wan Rong,Wang Yao,Wang Peng,Wang Jintang. Synthesis and Biological Activity of 1,3,4-Thiadiazole Aroylurea Derivatives[J]. Chinese Journal of Organic Chemistry, 2010, 30(1): 132-136 |
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| Authors: | Han Feng Wan Rong Wang Yao Wang Peng Wang Jintang |
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| Affiliation: | (Department of Applied Chemistry，Nanjing University of Technology，Nanjing 210009) |
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| Abstract: | Ten novel benzoyl ureas containing a 1.3,4-thiadiazole group were synthesized by the reaction of 2-amino-5-substituted phenyl-1,3,4-thiadiazole and 2,6-dinuorobenzoyl isocyanate,and structurally confirmed by ~1H NMR,IR,ESI-MS techniques and elemental analysis.Preliminary bioassay test indicated that some compounds showed insecticidal activity.Compounds 3d(3,5-(CH_3)_2)and 3g(4-C_4H_9)exhibit good insecticidal activity against Aphis craccivora with higer than 90% mortality. |
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| Keywords: | 1,3,4-thiadiazole aroyl urea synthesis biological activity |
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