Cytotoxic effect and electrophysiological study on human MRC-5 fibroblasts of R-irniine, a natural alkylpyrrolidine alkaloid |
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| Authors: | Lamkadem Mohammed Aziz Mohamed Schwob Isabelle Rabier Jacques Mimouni Jamal Fontonge Robert Melhaoui Ahmed |
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| Institution: | Laboratory of Phytochemistry and Pharmacognosy, University Mohamed Ier, Route Sidi Maafa, B.P. 524, 60000, Oujda, Morocco. |
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| Abstract: | R-irniine is a natural 2-alkylpyrrolidine alkaloid extracted from Arisarum vulgare Targ., a species belonging to the Araceae family known in Morocco for its toxicity. Cytotoxic and electrophysiological studies of this compound on human MRC-5 fibroblasts were carried out. Cytotoxic potential of R-irniine was detected on MRC-5 fibroblasts at 40 microg/mL. We carried out the electrophysiological study of this compound on MRC-5 cells by using the technique of patch-clamp in "Whole cell" configuration. R-irniine showed no effect on the outward potassium current of the MRC-5 fibroblasts. |
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