| 微波辅助酸催化水相一锅高效合成吖啶酸 |
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| 引用本文： | 许根瑞,李伟强,吴沁,黄超. 微波辅助酸催化水相一锅高效合成吖啶酸[J]. 化学通报, 2022, 85(8): 981-986 |
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| 作者姓名： | 许根瑞 李伟强 吴沁 黄超 |
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| 作者单位： | 云南民族大学,云南民族大学,云南民族大学,云南民族大学 |
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| 基金项目： | 国家自然科学基金项目(21662046,21202142)资助 |
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| 摘 要： | 本文建立一种以去离子水为溶剂，在微波辅助酸催化下一锅串联高效合成吖啶酸的新方法，该反应条件温和、操作简单、绿色高效。在优化反应条件下考察了多种取代基团对反应的影响，结果显示该方法具有良好的适应性，以83%～97%收率得到18个吖啶酸化合物。所有化合物结构均经过1H NMR、13C NMR、HRMS、熔点等表征确认。
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| 关 键 词： | 吖啶酸 微波辅助 一锅法 酸催化 绿色化学 |
| 收稿时间： | 2021-12-29 |
| 修稿时间： | 2022-01-25 |
Microwave-Assisted Acid Catalyzed One-Pot Efficient Synthesis of Acridine Acid in Aqueous Phase |
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| xu gen rui,li wei qiang,wu qin and huang chao. Microwave-Assisted Acid Catalyzed One-Pot Efficient Synthesis of Acridine Acid in Aqueous Phase[J]. Chemistry, 2022, 85(8): 981-986 |
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| Authors: | xu gen rui li wei qiang wu qin huang chao |
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| Affiliation: | Yunnan Minzu University,Yunnan Minzu University,Yunnan Minzu University,Yunnan Minzu University |
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| Abstract: | In this paper, a new method of one-pot series efficient synthesis of acridine carboxylic acid catalyzed by microwave-assisted acid with deionized water as solvent is established. The reaction conditions are mild, easy to operate, green and efficient. Under the optimized reaction conditions, we investigated the influence of various substituent groups on the reaction. The results showed that the method had good adaptability, and 12 acridine carboxylic acid compounds were obtained in 83% ~ 97% yield. All compounds were characterized by 1H NMR, 13C NMR, HRMS and melting point. |
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| Keywords: | Acridine acid Microwave assisted One pot method Acid catalysis Green chemistry |
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