Regio- and stereoselective synthesis of 2-amino-1,3-diene derivatives by ruthenium-catalyzed coupling of ynamides and ethylene |
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| Authors: | Saito Nozomi Saito Keiichi Shiro Motoo Sato Yoshihiro |
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| Institution: | Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. nozomi-s@pharm.hokudai.ac.jp |
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| Abstract: | A ruthenium-catalyzed hydrovinylation-type cross-coupling of ynamides and ethylene proceeds via ruthenacyclopentene to give 2-aminobuta-1,3-diene derivatives in a highly regioselective manner. It was also demonstrated that 2-aminobuta-1,3-diene derivatives reacted with various dienophiles or singlet oxygen to give a cyclic enamide derivative. |
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