Backscattering interferometry: an alternative approach for the study of hydrogen bonding interactions in organic solvents |
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Authors: | Pesciotta Esther N Bornhop Darryl J Flowers Robert A |
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Affiliation: | Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, United States. |
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Abstract: | Intermolecular interactions involving hydrogen bonds are responsible for catalysis and recognition. Traditional methods used to study hydrogen-bonding interactions are generally limited to relatively large volumes and high substrate concentrations. Backscattering Interferometry (BSI) provides a microfluidic platform to study these interactions in nonaqueous media at micromolar to nanomolar concentrations in picoliter volumes by monitoring changes in the refractive index. |
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