Substitution effect on the regioselective halogen/metal exchange of 3-substituted 1,2,5-tribromobenzenes |
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| Authors: | Karsten Menzel Todd D. Nelson |
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| Affiliation: | Merck Research Laboratories, Department of Process Research, Merck & Co., Inc., 466 Devon Park Drive, Wayne, PA 19087, United States |
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| Abstract: | Regioselective halogen/metal exchange reactions using isopropylmagnesium chloride were studied on 3-substituted 1,2,5-tribromoarenes. Seven examples are given. |
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| Keywords: | 1,2-Dibromobenzene Grignard reactions Halogen/metal exchange Regioselectivity Carboxylic acids |
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