| 差示扫描量热法(DSC)定量测试阿德福韦酯晶型的研究 |
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| 引用本文： | 袁钻如,张爱明,方江邻. 差示扫描量热法(DSC)定量测试阿德福韦酯晶型的研究[J]. 分析测试技术与仪器, 2008, 14(2): 105-108 |
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| 作者姓名： | 袁钻如 张爱明 方江邻 |
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| 作者单位： | 南京大学,现代分析中心,江苏,南京,210093;江苏正大天晴药业股份有限公司,江苏,连云港,222006 |
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| 摘 要： | 红外光谱（FTIR）和x-射线衍射（XRD）测试表明阿德福韦酯药物具有A、E2种晶型．利用差示扫描量热法（DSC）对阿德福韦酯药物的不同晶型进行了定量测试方法的研究，该方法的依据是药物的不同晶型具有不同的熔点和熔融热焓，根据熔融热焓的量可以定量测试药物中某种晶型的含量，为指导生产工艺研究和产品品质的判断提供快速准确及有效的测试方法。
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| 关 键 词： | 阿德福韦酯 晶型 差示扫描量热法 红外光谱 X-射线衍射 定量测试 |
| 收稿时间： | 2008-03-10 |
| 修稿时间： | 2008-04-16 |
Study on Quantitative Analysis of Crystal forms of Adefovir Dipivoxil by Differential Scanning Calorimetry |
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| YUAN Zuan-ru,ZHANG Ai-ming and FANG Jiang-lin. Study on Quantitative Analysis of Crystal forms of Adefovir Dipivoxil by Differential Scanning Calorimetry[J]. Analysis and Testing Technology and Instruments, 2008, 14(2): 105-108 |
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| Authors: | YUAN Zuan-ru ZHANG Ai-ming FANG Jiang-lin |
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| Affiliation: | Center for Morden Analysis of Nanjing University, Nanjing 210093, China;Jiangsu Chia Tal-tianqing Pharmaceutical Co Ltd, Lianyungang 222006, China;Center for Morden Analysis of Nanjing University, Nanjing 210093, China |
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| Abstract: | Adefovir dipivoxil contains two crystal forms of A and E by analysis of Fourier transform infrared spectroscopy(FTIR)and X-ray diffractometer(XRD).It is certified that the Quantitative Analysis of Crystal forms of Adefovir dipivoxil can be used by the method of Differential Scanning Calorimetry(DSC).The method is based on the principle that different crystal forms show the different melting point and molten enthalpy.The molten enthalpy is corresponding to the amount of the crystal form.It is a useful and rapid method of guiding the production technology and the control of product quality. |
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| Keywords: | adefovir dipivoxil crystal form DSC FTIR XRD quantitative analysis |
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