| 人工神经网络—近红外光谱法用于甲氧苄胺嘧啶粉末药品的非？… |
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| 引用本文： | 刘培义,汤真.人工神经网络—近红外光谱法用于甲氧苄胺嘧啶粉末药品的非？…[J].高等学校化学学报,2000,21(4):544-546. |
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| 作者姓名： | 刘培义 汤真 |
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| 作者单位： | 吉林大学化学系!长春130023(刘培义，任玉林，苟玉慧，郭晔，王宗睦)，中国人民解放军第208医院药剂科!长春130061(汤真田丽容)，满洲里进出口商品检验局!满洲里021400(杜玉荣) |
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| 摘 要： | 近红外(NIR)光谱分析技术已应用于制药、化妆品、烟草、食品、化学药品、聚合物、纺织品、油漆涂料、煤炭和石油工业等各个领域的质量监控.近年来,NIR光谱分析技术也应用于药品分析中,因该方法具有非破坏性,样品不需要复杂的预处理和分离即可直接测定.它可对药物进行定性和定量测定以及多晶、光学异构体和湿度的测定.近红外光谱法用于无损非破坏测定胶囊类以及片剂的研究已有报道1,2].NIR光谱在使用中也有一定的局限性,主要是结构复杂,谱图重叠多,在进行定性和定量分析中需采用一定的数据处理才能获得准确可靠的分析结果.在定量分析中,…
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| 关 键 词： | 人工神经网络 近红外光谱 甲氧苄胺嘧啶 |
Nondestructive Quantitative Analysis of Trimethoprim Powder Pharmaceutical by Artificial Neural Network and Near-infrared Spectroscopy |
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| LIU Pei-Yi,REN Yu-Lin,GOU Yu-Hui,GUO Ye,WANG Zong-Mu,TANG Zhen,TIAN Li-Rong,DU Yu-Rong.Nondestructive Quantitative Analysis of Trimethoprim Powder Pharmaceutical by Artificial Neural Network and Near-infrared Spectroscopy[J].Chemical Research In Chinese Universities,2000,21(4):544-546. |
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| Authors: | LIU Pei-Yi REN Yu-Lin GOU Yu-Hui GUO Ye WANG Zong-Mu TANG Zhen TIAN Li-Rong DU Yu-Rong |
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| Abstract: | The application of artificial neural network for pharmaceutical nondestructive quantitative analysis was investigated. The real data set from near infrared reflectance spectra of trimethoprim powder pharmaceutical were used to built up artificial network to predict unknown samples. The factors affecting network were discussed. A new network evaluation criterion, the degree of approximation, was employed. Owing to good nonlinear multivariate calibration nature of ANN, the predicted result was reliable. WT5HZ] |
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| Keywords: | Artificial neural network(ANN) Near infrared spectrophotometry Degree of approximation Trimethoprim |
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