Taxane diterpenoids from seeds of Taxus mairei |
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| Authors: | Shen Y C Chen C Y Hung M C |
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| Institution: | Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw |
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| Abstract: | A new 2(3-->20) abeotaxane, taxumairone A (1), and a new cis-p-coumaroyl myo-inositol have been isolated from the seeds of Taxus mairei in addition to taxin B (2), taxinine A, taxuspine X, decinnamoyltaxinine E, 5alpha-cinnamoyloxy-9alpha,10beta,13alpha- triacetoxy-taxa-4(20)11-diene and 5alpha-cinnamoyloxy-2alpha,9alpha,10beta,+ ++13alpha-tetraacetoxy-taxa-4(20)11-diene. The structure of 1 was determined by 2D-NMR spectral analysis and chemical correlation with taxin B (2). Compound 1 exhibited potent cytotoxicity against human colon carcinoma cells with an ED50 of 0.1 microg/ml. |
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