| 应用2D NMR技术研究罗汉果醇及其苷的结构 |
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| 引用本文： | 杨秀伟,张建业.应用2D NMR技术研究罗汉果醇及其苷的结构[J].波谱学杂志,2007,24(3):249-260. |
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| 作者姓名： | 杨秀伟 张建业 |
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| 作者单位： | 北京大学,药学院,天然药物及仿生药物国家重点实验室,北京,100083;北京大学,药学院,天然药物及仿生药物国家重点实验室,北京,100083 |
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| 基金项目： | 国家高技术研究发展863计划(2002AA2Z343C)，北京市科技专项(Z0004105040311)资助项目. |
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| 摘 要： | 从传统中药罗汉果中分离得到一系列三萜皂苷类化合物，其苷元为罗汉果醇，应用1D和2D NMR脉冲梯度场反相技术(gCOSY，gNOESY，gHMQC，gHMBC) 研究了罗汉果醇及其苷的结构，对其碳氢NMR信号进行了全归属，应用gNOESY技术研究了罗汉果醇的立体构型，并探讨了取代基对苷元质子和碳化学位移的影响.
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| 关 键 词： | 核磁共振 归属 结构 2D NMR 罗汉果醇 罗汉果皂苷 罗汉果 |
| 文章编号： | 1000-4556（2007）03-0249-12 |
| 收稿时间： | 2007-1-15 |
| 修稿时间： | 2007-01-152007-03-16 |
NMR Structural Elucidation of Mogrol and Its Glycosides |
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| YANG Xiu-wei,ZHANG Jian-ye.NMR Structural Elucidation of Mogrol and Its Glycosides[J].Chinese Journal of Magnetic Resonance,2007,24(3):249-260. |
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| Authors: | YANG Xiu-wei ZHANG Jian-ye |
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| Institution: | The State Key Laboratory of Natural & Biomimetic Drugs，School of Pharmaceutical Sciences，Peking University，Beijing 100083，China |
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| Abstract: | Mogroside Ⅲ was isolated from the fruit of Momordica grosvenori SwingleSiraitia grosvenorii(Swingle) C. Jeffery]. Mogrol (9β-methyl-19-norlanost-5- ene-3β，11α，24β, 25-tetrol) was derived from mogroside Ⅲ by mild enzymatic hydrolysis. One-dimensional and two-dimensional NMR(including gCOSY，gNOESY，gHSQC and gHMBC) techniques were employed to assign the chemical shifts and elucidate the structures of the compounds. The effects of the substitutent groups on the 1H and 13C chemical shifts of the mogroside were also discussed. |
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| Keywords: | NMR structure mogrol mogrosides Momordica grosvenori |
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