Immunomodulatory action of monosulfated triterpene glycosides from the sea cucumber Cucumaria okhotensis: stimulation of activity of mouse peritoneal macrophages |
| |
| Authors: | Aminin Dmitry L Silchenko Alexandra S Avilov Sergey A Stepanov Vadim G Kalinin Vladimir I |
| |
| Institution: | Pacific Institute of Bioorganic Chemistry, Vladivostok 690022, Russian Federation. |
| |
| Abstract: | Six monosulfated triterpene glycosides, frondoside A1 (1), okhotoside B1 (2), okhotoside A1-1 (3), frondoside A (4), okhotoside A2-1 (5) and cucumarioside A2-5 (6), isolated from Cucumaria okhotensis Levin et Stepanov, stimulate spreading and lysosomal activity of mouse macrophages and ROS-formation in the macrophages. The highest macrophage spreading and stimulation of their lysosomal activity was induced by glycosides 1, 4 and 6. All glycosides similarly stimulate ROS formation in macrophages, but glycoside 2 caused minimal stimulation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
