Three new 18-oxygenated ent-kaurane diterpenoids from Isodon leucophyllus |
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| Authors: | Zhang Hai Bo Pu Jian Xin Zhao Yong He Fei Zhao Wei Lou Li Guang Xiao Wei Lie Sun Han Dong |
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| Institution: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China. |
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| Abstract: | Three new 18-oxygenated ent-kaurane diterpenoids, isoleuconins A-C (1-3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis. All of the compounds were evaluated for their cytotoxicity. Rabdokunmin A (13) showed significant cytotoxicity against HT-29 cells, with an IC50 value of 6.2 microM. |
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