Horseradish peroxidase catalyzed oxidative cross-coupling reactions: the synthesis of ‘unnatural’ dihydrobenzofuran lignans |
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Authors: | Francesco Saliu Eeva-Liisa TolppaLuca Zoia Marco Orlandi |
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Affiliation: | Department of Environmental Science, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milano, Italy |
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Abstract: | The possibility to afford by a biomimetic reaction ‘unnatural’ products, which could offer a better bioactivity profile than natural analogues, is outlined and the first applications to the synthesis of lignans and related compounds have been reported. Here we describe the synthesis of new heterodimers, having a phenylcoumaran skeleton, by horseradish peroxidase catalyzed cross-coupling reactions of methyl esters of substituted hydroxycinnamic acids. |
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Keywords: | Dihydrobenzofuran lignans Radical cross-coupling reaction Horseradish peroxidase |
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