Synthesis of functionalized piperidinones |
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| Authors: | Humphries Mark E Murphy James Phillips Andrew J Abell Andrew D |
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| Institution: | Department of Chemistry, University of Canterbury, Christchurch, New Zealand. |
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| Abstract: | A versatile, stereoselective synthesis of 5-hydroxypiperidinones with substituents at N1, C3, and C6 has been developed. The sequence involves ring-closing metathesis of a diene amide and epoxidation of the resulting alkene, followed by base-mediated elimination, and finally hydrogenation. |
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