Size characterization of drug-loaded polymeric core/shell nanoparticles using asymmetrical flow field-flow fractionation |
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Authors: | Dong Young Kang Mi Jung Kim Sun Tae Kim Keun Sang Oh Soon Hong Yuk Seungho Lee |
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Institution: | (1) Department of Chemistry, Hannam University, Daejeon, 305–811, Korea;(2) Department of Polymer Science and Engineering, Hannam University, Daejeon, 305–811, Korea |
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Abstract: | Asymmetrical flow field-flow fractionation (AsFlFFF) was used to determine the size distribution of drug-loaded core/shell
nanoparticles which have a lipid core of lecithin and a polymeric shell of a Pluronic. AsFlFFF provided separation of the
drug-loaded core/shell nanoparticles from smaller coreless polymeric micelles, thus allowing accurate size analysis of the
drug-loaded nanoparticles without interference by the coreless micelles. It was found from AsFlFFF that the drug-loaded nanoparticles
have broad size distributions ranging from 100 to 600 nm in diameter. It was also found that, after the nanoparticles had
been stored for 70 days, they disappeared as a result of self-degradation. Being a separation technique, AsFlFFF seems to
be more useful than transmission electron microscopy or dynamic light scattering for size analysis of core/shell nanoparticles,
which have broad and bimodal size distributions.
Figure Separation by AsFlFFF |
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Keywords: | Asymmetrical flow field-flow fractionation Hydrodynamic diameter Drug-loaded core/shell nanoparticles Size distribution |
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