ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme |
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| Authors: | Casini Angela Mastrobuoni Guido Temperini Claudia Gabbiani Chiara Francese Simona Moneti Gloriano Supuran Claudiu T Scozzafava Andrea Messori Luigi |
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| Institution: | Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy. |
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| Abstract: | The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15. |
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