| Synthesis of unsaturated phosphatidyl inositol-3,4,5-trisphosphate |
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| 作者姓名： | 尾崎庄一郎 孔祥正 渡边裕 小笠原富夫 |
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| 作者单位： | Department of Chemistry，Shandong University，Jinan，Shandong 250100，China，Department of Chemistry，Shandong University，Jinan，Shandong 250100，China，Department of Applied Chemistry，Faculty of Engineering，Ehime University，Matsuyama，790，Japan，Department of Applied Chemistry，Faculty of Engineering，Ehime University，Matsuyama，790，Japan |
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| 摘 要： | Phosphatidylinositol polyphosphate (PIPx) are related with tyrosine kinase activation and cell proliferation and carcinogenesis. PIPx is an important target compound for synthetic organic chemist. PIPx having saturated fatty acid components have been reported. Recently we have succeeded in the synthesis of phosphatydylinositol-3,4,5-trisphosphate with unsaturated fatty acid component by the reaction of diethyl chlorophosphite with l,2-di-O-cyclohexylidene-3,4-O-(tetraisopropyldisiloxane 1,3-diyl)-6-O-(4-oxopentanoyl)-myo-inositol.
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Synthesis of unsaturated phosphatidyl inositol-3,4,5-trisphosphate |
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| OZAKI,Shoichiro KONG,Xiang-ZhengWATANABE,Yutaka OGASAWARA,Tomio.Synthesis of unsaturated phosphatidyl inositol-3,4,5-trisphosphate[J].Chinese Journal of Chemistry,1998,16(1):51-57. |
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| Authors: | OZAKI Shoichiro KONG Xiang-ZhengWATANABE Yutaka OGASAWARA Tomio |
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| Institution: | OZAKI,Shoichiro KONG,Xiang-ZhengWATANABE,Yutaka OGASAWARA,TomioDepartment of Chemistry,Shandong University,Jinan,Shandong 250100,China Department of Applied Chemistry,Faculty of Engineering,Ehime University,Matsuyama,790,Japan |
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| Abstract: | Phosphatidylinositol polyphosphate (PIPx) are related with tyrosine kinase activation and cell proliferation and carcinogenesis. PIPx is an important target compound for synthetic organic chemist. PIPx having saturated fatty acid components have been reported. Recently we have succeeded in the synthesis of phosphatydylinositol-3,4,5-trisphosphate with unsaturated fatty acid component by the reaction of diethyl chlorophosphite with l,2-di-O-cyclohexylidene-3,4-O-(tetraisopropyldisiloxane 1,3-diyl)-6-O-(4-oxopentanoyl)-myo-inositol. |
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| Keywords: | 1-(1' 2'-Di-O-oleoyl-3'-sn-phosphatidyl)-myo-inositol-3 4 5-tris(hydrogen phosphate) myo-inositol unsaturated fatty acid PI-3 4 5-P3 |
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