Pyrazolidine-3,5-dione angiotensin-II receptor antagonists

The crystal structures of three angiotensin-II receptor antagonists involving different spacer groups (CO, CONH and NHCO) between the aryl rings are presented, namely 2-{4-(3-butyl-1,4-dioxo-2,3-di­aza­spiro­4.4]­non-2-yl)­methyl]­benzoyl}benzoic acid, C₂₆H₂₈N₂O₅, (I), 2-{4-(3-butyl-1,4-dioxo-2,3-di­aza­spiro­4.4]­non-2-yl)­methyl]­benz­amido}benzoic acid, C₂₆H₂₉N₃O₅, (II), and 2-{4-(3-butyl-1,4-dioxo-2,3-di­azaspiro­4.4]­non-2-yl)­methyl]­anilino­carbonyl}benzoic acid monohydrate, C₂₆H₂₉N₃O₅·H₂O, (III). The aryl rings of (II) are almost coplanar, in contrast with compounds (I) and (III). The conformation of (II) is induced by an intramolecular N—H⋯O hydrogen bond between the amide and carboxyl­ic acid groups.