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Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid |
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| Authors: | Shuwen He C. Scott Shultz Zhong LaiRonsar Eid Peter H. DobbelaarZhixiong Ye Ravi P. Nargund |
| Affiliation: | a Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA b Department of Process Research, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA |
| Abstract: | Asymmetric hydrogenation of achiral spiroindene dimethyl acetic acid 2 with 4% of Ru(II)-Mandyphos in acetone produced (S)-spiroindane dimethyl acetic acid 1 in 86% isolated yield and 96.8:3.2 enantiomeric ratio. |
| Keywords: | Asymmetric hydrogenation Ruthenium Chiral phosphine Spiroindane |
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