One-pot synthesis of chiral azetidines from chloroaldehyde and chiral amines |
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| Authors: | Suvi TM Orr Shawn CabralDilinie P Fernando Teresa Makowski |
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| Institution: | Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA |
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| Abstract: | A variety of chiral azetidinepiperidines have been synthesized utilizing an expedient one-pot union of piperidine chloroaldehyde with chiral amines. This two step one-pot procedure provides access to an interesting set of compounds that retain the chiral purity of the starting chiral amine. |
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| Keywords: | Azetidines Chiral amines Reductive amination |
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