| STRUCTURE OF (Trp)~(B1)-INSULIN AT 2RESOLUTION |
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| 引用本文： | 李军,毕汝昌,梁丽,林政炯,雷克健.STRUCTURE OF (Trp)~(B1)-INSULIN AT 2RESOLUTION[J].中国科学B辑(英文版),1986(1). |
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| 作者姓名： | 李军 毕汝昌 梁丽 林政炯 雷克健 |
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| 作者单位： | Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing，Institute of Biophysics，Academia Sinica，Beijing |
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| 摘 要： | The rhombohedral crystal structure of Trp]~(B1)-insulin has been refined, using data to 2 and atomic coordinates of 2-zinc porcine insulin as starting model, and through the use of the restrained least-squares method, to an R value of 0.24. The result of refinement shows that in comparison with the 2-zinc insulin structure, some changes in local conformation occur, and are asymmetric for the two independent molecules related by a local two-fold axis. The obvious conformational changes are found to be in molecule 1, at its B-chain N-terminus and A13-residue region.
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