CSTR和批式反应器中酶法拆分萘普生的比较

比较了批式反应器和连续流动搅拌反应器中酶动力学拆分萘普生的不同之处。从宏观反应器平衡角度，推导出了在ＣＳＴＲ中不同于在批式反应器中的酶立体选择性，产物对映体过量值和反应转化率的定量关系式，并通过脂肪酶催化的萘一甲酯的不对称水解反应得到了证实。

Comparison between Enzymatic Kinetic Resolution of Naproxen in Batch Reactor and CSTR

The difference between a continuous stirred-tank reactor (CSTR) and a batchwise reactor has been shown for the enzymatic kinetic resolution of naproxen. By macroscopic reactor balancing, new quantitative relationships between enzyme enantioselectivity, product enantiomeric excess and the extent of conversion have been deduced for chiral resolution in a CSTR. They were experimentally verified by the lipase-catalyzed asymmetric hydrolysis of racemic naproxen methyl ester. The stereoseIective hydrolysis reaction was performed both in a batch system and a CSTR. At a particular conversion slightly higher enantiomeric excess of product can be obtained in a batch system. Under similar reaction conditions a higher conversion can be obtained in a batch system. After 1200 h continuous operation, the immobilized lipase running in a batch reactor reserves 65% of its original activity and running in a CSTR reserves 80%, that is, the immobilized lipase is more stabe in a CSTR.