KINETIC AND SPECTROSCOPIC EFFECTS OF PROTEIN-CHROMOPHORE ELECTROSTATIC INTERACTIONS IN BACTERIORHODOPSIN |
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| Authors: | A Warshel M Ottoenghi ‡ ‡ |
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| Institution: | Department of Chemistry, University of Southern California, Los Angeles, CA 90007;, U.S.A. ‡Department of Physical Chemistry, The Hebrew University. Jerusalem, Israel |
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| Abstract: | Abstract— Available pH effects on the absorption spectrum and on the rates of dark adaptation (all- trans → 13 -cis interconversion) of bacteriorhodopsin are analyzed in terms of a model based on protein-chromophore electrostatic interactions. Plausible locations of three protein acid-base groups controlling the spectrum and the activation energy of the thermal trans → 13- cis process are suggested. The importance of the protein charges in controlling the cycles of bacteriorhodopsin is indicated. |
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