Recognition of secondary structures in proteins by a diiron(III) complex via a hydrolytic pathway |
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| Authors: | Pan Qunhui Jiang Wei Liao Zhanru Zhang Tianle Liu Changlin |
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| Affiliation: | Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China. |
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| Abstract: | The diiron(III) complex Fe(2)(DTPB)(mu(2)-O)(mu(2)-OAc)Cl(BF(4))(2) [DTPB = 1,1,4,7,7-pentakis(2'-benzimidazol-2-yl-methyl)triazaheptane, OAc = acetate] exhibits a similar affinity for proteins belonging to different structural patterns. However, this diiron complex is sensitive to secondary structures in a protein when it is used to promote the protein hydrolysis, indicating that some metal complexes, such as artificial proteolytic agents, could become a new hydrolytic probe of protein structures. |
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