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Temperature sensitive dendrite-shaped PNIPAAm/Dex-AI hybrid hydrogel particles: formulation and properties
Authors:Xian-Zheng Zhang
Institution:Department of Textiles and Apparel and Biomedical Engineering Program, Cornell University, Ithaca, NY 14853-4401, USA
Abstract:The development of a new temperature sensitive hydrogel particle having biodegradable crosslinkages, composed of poly(N-isopropylacrylamide)/dextran-allyl isocyanate (PNIPAAm/Dex-AI) was prepared through precipitation polymerization. Dex-AI was used as a precursor as well as a biodegradable crosslinker for forming the network particles. Characterization data showed that these PNIPAAm/Dex-AI hydrogel particles had an average hydration diameter around 1.0 mm and showed a dendrite-like heterogeneous morphology with two different porous microstructures. The hydrogel particles exhibited a transition temperature or lower critical solution temperature (LCST) at around 25.7 °C through differential scanning calorimetry (DSC) measurement or temperature dependence study of particles volume. The freeze-dried particles swelled quickly when socked in distilled water at room temperature and large amounts of water were stored within the network before reaching the stable swollen state.
Keywords:Hydrogel  Dendrite-shape particle  PNIPAAm/Dex-AI  Biodegradable  Temperature sensitive  Precipitation polymerization
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