Development
of thermogravimetric method to quantitative determination of mebendazole |
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Authors: | Ana Paula Barrêto Gomes Lidiane Pinto Correia Mônica Oliveira da Silva Simões Rui Oliveira Macêdo |
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Institution: | 1.Federal University
of Paraíba UFPB, Unified Development and Medicine Assays Laboratories
LUDEM,Cidade Universitária,Jo?o Pessoa,Brazil |
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Abstract: | The objective of this work was to develop and validate a fast and reproducible
method able to determine the concentration of mebendazole in raw materials
and tablets. The samples were analyzed by dynamic thermogravimetry, in the
heating rates of 10, 20, 40, 60 and 80°C min–1,
in the atmospheres of nitrogen and nitrogen with synthetic air. Obtained data
were used in the equations of Antoine and Langmuir, with the purpose to get
the pressure curves of those. Vapor pressure curves of drug and tablet of
mebendazole were evaluated using the mathematical indexes of difference factor, f
1, and similarity factor, f
2, to compare its profiles.
The data showed that there is no significant difference between the vapor
pressure profiles of drug and tablet of mebendazole in both environmental
conditions studied, what confirms that the process is really vaporization.
The concentration of mebendazole was determined in the raw material and tablets
with the drug. |
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Keywords: | equation of Antoine equation of Langmuir mebendazole thermogravimetry vapor pressure |
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