Posttraumatic secondary brain insults exacerbates neuronal injury by altering Metabotropic Glutamate Receptors |
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| Authors: | Zhou Fei Xiang Zhang Hong-min Bai Xiao-fan Jiang Xia Li Wei Zhang Wei Hu |
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| Institution: | (1) Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, P.R.China;(2) Department of Neurosurgery, Guang Zhou Liuhuaqiao Hospital, 510010 Guang Zhou, P.R.China |
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| Abstract: | Background Our previous studies indicated that metabotropic glutamate receptors (mGluRs) are deeply involved in the secondary processes
after diffuse brain injury (DBI). In the present study, we used a rodent DBI model to determine whether hypotension exacerbates
neuronal injury as a secondary brain insult (SBI) after traumatic brain injury (TBI) by changing the expression of metabotropic
glutamate receptors (mGluRs) in the cerebral cortex. |
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