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Lobozoanthamine, a new zoanthamine-type alkaloid from the Indonesian soft coral Lobophytum sp.
Authors:Ernesto Fattorusso  Orazio Taglialatela-Scafati  M. Janib Achmad  Carlo Cerrano
Affiliation:a Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli ‘Federico II’, Via D. Montesano 49, 80131 Napoli, Italy
b Faculty of Fisheries and Marine Sciences, Sam Ratulangi University, 95115 Manado, Indonesia
c Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
d Dipartimento per lo Studio del Territorio e delle sue Risorse, Università di Genova, Corso Europa 26, 16132 Genova, Italy
Abstract:A new member of the family of zoanthamine-type alkaloids, lobozoanthamine (1), has been isolated from the Indonesian soft coral Lobophytum sp. This represents the first report of a zoanthamine-type alkaloid from a marine invertebrate different from zoanthids. The densely functionalized heptacyclic stereostructure of lobozoanthamine (1) has been established through the interpretation of 2D NMR data and application of the modified Mosher method.
Keywords:Lobophytum sp.   Indonesia   Zoanthamine   Alkaloids   Structure elucidation   NMR
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