Preparation of silyl enol ethers from acyloin derivatives using silyllithium reagents |
| |
Authors: | Bradley D Robertson |
| |
Institution: | Department of Chemistry, Winthrop University, Rock Hill, SC 29733, USA |
| |
Abstract: | A new method for the regioselective preparation of silyl enol ethers from acyloin derivatives using silyllithium reagents has been developed. Both dimethylphenyl- and methyldiphenylsilyllithium were found to be effective, the latter providing greater stereocontrol. The reaction is believed to proceed via Brook rearrangement assisted by expulsion of the adjacent leaving group. A number of acyclic acyloin derivatives were reacted to form the corresponding silyl enol ethers in good to excellent yield. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|