Microwave-assisted synthesis of 4-quinolylhydrazines followed by nickel boride reduction: a convenient approach to 4-aminoquinolines and derivatives |
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| Authors: | Sandra Gemma Gagan Kukreja Pierangela Tripaldi Maria Altarelli Matteo Bernetti Silvia Franceschini Luisa Savini Giuseppe Campiani Caterina Fattorusso |
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| Affiliation: | a European Research Centre for Drug Discovery and Development, Università di Siena, via Aldo Moro, 53100 Siena, Italy
b Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy |
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| Abstract: | Nickel(II) chloride/sodium borohydride combination was employed for the reduction of 4-hydrazinoquinoline derivatives to the corresponding anilines. This reductive protocol was efficiently applied for the reductive cleavage of monosubstituted hydrazines. We described herein the microwave-assisted synthesis of 4-hydrazinoquinolines, which furnished a high yielding and rapid two-step procedure for the synthesis, under mild conditions, of 4-aminoquinolines as antimalarial precursors. |
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| Keywords: | Nickel boride Reduction Hydrazines Microwave 4-Aminoquinolines |
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