Axiplyns A-E, new sesquiterpene isothiocyanates from the marine sponge Axinyssa aplysinoides |
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Authors: | Hagit Sorek Yehuda Benayahu |
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Institution: | a School of Chemistry, Tel-Aviv University, Ramat Aviv 69978, Israel b Department of Zoology, Tel-Aviv University, Ramat Aviv 69978, Israel |
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Abstract: | Five new isothiocyanate sesquiterpenes, designated axiplyns A-E (1-5) have been isolated, together with two known isothiocyanate sesquiterpenes (6, 7), from the sponge Axinyssa aplysinoides collected at Misali Island, Tanzania. Axiplyns 4 and 5 embody a new indane sesquiterpene skeleton, and compounds 1, 2, and 5 contain unprecedented ring systems, namely a 6,8-dioxabicyclo3.2.1]octane and a 2-oxabicyclo2.2.1]heptane. Axiplyns A, B, and C are potent brine shrimp toxins with LD50 values between 1.5 and 1.8 μg/mL. |
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Keywords: | Marine sponge Sesquiterpenoid Isothiocyanate NMR |
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