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Ugi four-component condensation with two cleavable components: the easiest synthesis of 2,N-diarylglycines |
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| Authors: | Cristina Faggi Stefano Marcaccini Gloria Menchi |
| Institution: | a CRIST, Centro Interdipartimentale di Cristallografia, Università di Firenze, via della Lastruccia 3, I-50019 Sesto Fiorentino (FI), Italy b HeteroBioLab, Dipartimento di Chimica Organica, Università di Firenze, via della Lastruccia 13, I-50019 Sesto Fiorentino (FI), Italy c Departamento de Química Orgánica, Facultad de Veterinaria, Universidad de Extremadura, Avenida de la Universidad s/n, E-10071 Cáceres, Spain d Instituto de Química Orgánica General—CSIC, Grupo de Química Orgánica Biológica, C/Juan de la Cierva 3, 28006 Madrid, Spain |
| Abstract: | The Ugi four-component condensation between anilines, aromatic aldehydes, isocyanides, and α-oxoacids afforded the expected adducts which were cleaved in mild conditions to give 2,N-diarylglycines in high yields. |
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