On-line coupling of liquid chromatography at critical conditions with electrospray ionization tandem mass spectrometry for the characterization of a nitroxide-mediated poly(ethylene oxide)/polystyrene block copolymer |
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Authors: | Girod Marion Phan Trang N T Charles Laurence |
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Affiliation: | Universités Aix-Marseille I, II & III - CNRS, UMR 6264, Spectrométries Appliquées à la Chimie Structurale, F-13397 Marseille Cedex 20, France. |
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Abstract: | Coupling of liquid chromatography at critical conditions (LCCC) with on-line mass spectrometry (MS) detection was implemented via an electrospray ionization (ESI) interface, using a mobile phase containing the cationizing agent. Critical conditions established for poly(ethylene oxide) were used to characterize a poly(ethylene oxide)/polystyrene block copolymer (PEO-b-PS) in both MS and MS/MS modes. As co-oligomer molecules were successfully separated according to the PS block size, structural information could be reached from simplified MS spectra. The microstructure of this copolymer, synthesized by nitroxide-mediated polymerization, could further be unambiguously characterized in LCCC/ESI-MS/MS experiments since the PS block size could be reached by both the co-oligomer chromatographic behavior and its MS/MS pattern. |
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