Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling |
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| Authors: | Moro Stefano Deflorian Francesca Spalluto Giampiero Pastorin Giorgia Cacciari Barbara Kim Soo-Kyung Jacobson Kenneth A |
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| Institution: | Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. stefano.moro@unipd.it |
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| Abstract: | We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands. |
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