Palladium-catalyzed, copper(I)-mediated coupling of boronic acids and benzylthiocyanate. A cyanide-free cyanation of boronic acids |
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| Authors: | Zhang Zhihui Liebeskind Lanny S |
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| Affiliation: | Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA. |
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| Abstract: | A new method for the synthesis of nitriles is described. As a complement to the classic cyanation of aryl halides using cyanide sources and a transition metal catalyst, the palladium-catalyzed cross-coupling of thiocyanates with boronic acids in the presence of copper(I) thiophene-2-carboxylate (CuTC) affords nitriles in good to excellent yields. |
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