Synthesis and structure of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohexahydropyrimidine-4-carboxylic acids |
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Authors: | A. Yu. Ershov D. G. Nasledov E. V. Parilova I. V. Lagoda V. V. Shamanin |
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Affiliation: | 1. Institute of Macromolecular Compounds, Russian Academy of Sciences, Bolshoi pr. V.O. 31, St. Petersburg, 199004, Russia 2. Research Test Center (of Medico-Biological Protection) of the State Research Test Institute of Military Medicine, Defense Ministry of the Russian Federation, St. Petersburg, Russia
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Abstract: | Proceeding from natural amino acid L-asparagine and commercially available aldehydes a stereoselective synthesis was developed of (2S,4S)-2-alkyl(aryl)-3-(3-sulfanylpropanoyl)-6-oxohydropyrimidine-4-carboxylic acids, potential antihypertensive drugs, inhibitors of the angiotensin converting enzyme. |
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